When Checkpoints Fail

When Checkpoints Fail

age during the segregation of sister chromatids. Checkpoints Monitor DNA Damage and Regulate Genetic studies have identified many of the compoCell Cycle Progression nents of checkpoints in the yeastsSaccharomyces cereA number of surveillance systems exist that interrupt visiae (reviewed in Murray, 1995) and Schizosaccharocell cycle progression when damage to the genome or myces pombe (reviewed ...

When Intuitions Fail

The title of this article looks in two different directions. It asks, "When do intuitions fail?" hoping to locate the conditions under which intuitions are likely to beunreliable.But it can also be the subordinate clause, of the question, "When intuitions fail, what can we do?": Both approaches, the remedial and the prophylactic, will be considered here. In 1951, Carl Voegelin and Zellig Harris...

When the Eyes Fail

When Antibiotics Appear to Fail

he patient was a 17-year-old unmarried, primi-gravida who delivered via vacuum-assisted vaginal extraction two days previously. In the course of the delivery, a significant midline and extensive right lateral wall vaginal tear occurred. The patient was discharged on the first postpartum day; however, she represented herself to the clinic 24 h later with shaking chills, a temperature of 103.3F, ...

Rerouting Flows When Links Fail

We introduce and investigate reroutable flows, a robust version of network flows in which link failures can be mitigated by rerouting the affected flow. Given a capacitated network, a path flow is reroutable if after failure of an arbitrary arc, we can reroute the interrupted flow from the tail of that arc to the sink, without modifying the flow that is not affected by the failure. Similar type...